内容摘要：So she turned it into a little “phone room” for herself. “It seemed like the perfect size and place to escape, with some privacy to make a call.”

So she turned it into a little “phone room” for herself. “It seemed like the perfect size and place to escape, with some privacy to make a call.”

and told Locke, at the time a UAB transplant surgeon, she’d like to try one. In April 2023, Locke filed an FDA application seeking an emergency experiment, under rules for people like Looney who are out of options.The FDA didn’t agree right away. Instead, the world’s first gene-edited pig kidney transplants went to two sicker patients last spring, at Massachusetts General Hospital and NYU. Both also had serious heart disease. The Boston patient recovered enough to spend about a month at home before dying of sudden cardiac arrest deemed unrelated to the pig kidney. NYU’s patient had heart complications that damaged her pig kidney, forcing its removal, and she later died.

Those disappointing outcomes didn’t dissuade Looney, who was starting to feel worse on dialysis but, Locke said, hadn’t developed heart disease or other complications. The FDA eventually allowed her transplant at NYU, where Locke collaborated with Montgomery.Moments after Montgomery sewed the pig kidney into place, it turned a healthy pink and began producing urine.Even if her new organ fails, doctors can learn from it, Looney told the AP: “You don’t know if it’s going to work or not until you try.”

Pig kidney recipient Towana Looney stands with transplant surgeons Dr. Jayme Locke, left, and Dr. Robert Montgomery, center, at NYU Langone Health. (AP Photo/Shelby Lum)Pig kidney recipient Towana Looney stands with transplant surgeons Dr. Jayme Locke, left, and Dr. Robert Montgomery, center, at NYU Langone Health. (AP Photo/Shelby Lum)

Blacksburg, Virginia-based Revivicor provided Looney’s new kidney from a pig with 10 gene alterations. Its parent company, United Therapeutics said Tuesday it plans to file an application with the FDA “very soon” to begin clinical trials with that type of kidney.

Looney was initially discharged on Dec. 6, wearing monitors to track her blood pressure, heart rate and other bodily functions and returning to the hospital for daily checkups before her medication readmission. Doctors scrutinize her bloodwork and other tests, comparing them to prior research in animals andAn influential government health panel recommends fluoride supplements for children between the ages of six months and 5 years if they live in areas with low fluoridation levels. The U.S. Preventative Services Task Forces judged the recommendation to have “high certainty,” based on the available evidence.

A 2010 paper from the ADA recommended supplemental fluoride for children up to 16 years old who are at high risk of cavities. The recommendation was based on a review of studies across different age groups. The most common side effect associated with the products is spotting or discoloration of the teeth, caused by extra fluoride.ADA’s Kessler said the FDA’s plan “will be particularly harmful to the most vulnerable and those who lack access to care.”

The FDA regulates most dental products, including fluoride-containing toothpastes, supplements, mouthwashes and rinses. But in Tuesday’s press release, the FDA said the ingestible products targeted by the agency have “never been approved.” The agency’s plan wouldn’t affect toothpastes, mouthwash or fluoride treatments used by adults or those offered in dentists’ offices.In recent weeks fluoride-containing products have increasingly been targeted with lawsuits and legal actions.